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What are transfer factors and how do they work? Soon after giving birth, female mammals produce colostrum, which is a milk-like substance that jump-starts a newborn's immune system. Researchers now believe that the benefits of colostrum don't necessarily end there. If you have a compromised immune system or are just looking for a boost to your healthy immune system, colostrum may be the jump-start you need to fight infection or immune-related chronic diseases such as cancer.
Transfer Factor is a set of messaging molecules that convey immune information within an individual's immune system. Nature also uses transfer factor to carry immune information from one individual's immune system to another individual. This in fact is how it got its name: by being the factor that transferred immunity from one person to another. Transfer factors are the primary communications used by the immune system to defend against harmful microbial threats. Transfer factors are small molecules that occur naturally in all mammals and are passed from mother to newborn through the mother's first milk called colostrum. By transferring information from cell to cell, transfer factors serve as "teachers" to the cells, ensuring a strong immune system capable of surviving, even thriving, in its new environment.
How was Transfer Factor discovered? In 1949 Dr. H. Sherwood Lawrence was working on the problem of tuberculosis. What he was trying to discover was if any component of the blood could convey a tubercular sensitivity from an exposed recovered donor to a naive recipient. Whole blood transfusions could be used but only between people of the same blood type. Lawrence first separated the blood's immune cells, the lymphocytes or white blood cells, from the whole blood. Then he broke open the lymphocytes and separated the contents of the cells into various size fractions. What he found was that a fraction of small molecules was able to transfer tuberculin sensitivity to a naive recipient. This is what Dr. Lawrence called transfer factor.
Transfer factors may become a valuable way to treat communicable disease in the future as researchers learn more and gain the ability to isolate specific factors. In fact, transfer factors may someday cure the diseases ravaging the world population, such as AIDS and Ebola. After the tragic 2002 Ebola outbreak in Uganda, freelance journalist Sam Wainaina explored the potential benefits of transfer factors in Africa. In his article, Wainaina concluded that had transfer factors been used during the outbreak, it could have been contained sooner, saving lives and avoiding mass hysteria.
Is blood the only source of transfer factor? Originally it was. It was not until the mid 1980's that two researchers came up with the idea that Transfer Factor may also be present in colostrum. The confirmation of this discovery was awarded a patent in 1989. Colostrum is now the best source of transfer factor.
What is colostrum? It is the first milk that a mother produces immediately after giving birth.
What prompted these scientists to look for Transfer Factor in colostrum? Those who have worked with cattle know that if a calf is not allowed to nurse from its mother it will most often die within a short time. The calves would die in spite of an abundance of food. Death in these cases was cause by infections brought on by the most common organisms. For whatever reason the immune systems of these calves were not working. Seeing this suggests that there is some kind of immune information was being transferred from the mother and her infant. The logical question then became: was it transfer factor? The answer was a resounding YES!
Transfer Factor™ is isolated from colostrum, what about milk allergies and lactose intolerance? Milk allergies are caused by the large milk proteins, primarily casein, and to a lesser extent the immunoglobulins. These proteins are completely removed from the transfer factor. Lactose intolerance is most common in Oriental populations; much less so in those of European or African decent. We are conscience of this concern and remove the lactose from our product.
Can persons who have milk allergies use Transfer Factor XF?
Yes. Transfer factors themselves are non-allergenic. Common allergens such as immunoglobulins and casein are removed from Transfer Factor products.
Can persons who are lactose intolerant use Transfer Factor XF?
Yes! Lactose intolerant persons can consume up to three grams of lactose without difficulty due to colonic bacterial digestion. The amount of residual lactose is well below these sensitivity limits.
Are there any differences between dried colostrum and 4Life’s Transfer Factor XF?
Unlike colostrum, Transfer Factor XF contains a concentrated amount of transfer factors, the active ingredient found in colostrum. Through a special patented process licensed to 4Life, transfer factors are separated from other components found in this “first milk.” Transfer factors readily survive digestion and are easily absorbed, unlike the antibodies and proteins found in colostrum. In addition, Transfer Factor XF has undergone a special stabilization process to protect the effectiveness of the transfer factors.
How does Transfer Factor™ compare to the colostrum products that are on the market now? We looked seriously at hyperimmunized colostrum and eggs. These products are good but certain issues must be addressed. First the milk allergy and lactose intolerance issues as we discussed above. Second the issue of immunoglobulin or antibody effectiveness. The use of cross species antibody therapy can be effective in the short run. Long-term use is ineffective since the recipient develops antibodies to the foreign antibody thus destroying its effectiveness. Antibody therapy is given intravenously since oral consumption leads to acid degradation in the stomach.
Is Transfer Factor™ only good for newborns? Transfer Factor is good for everyone who needs an extra immune boost. The three groups who are most in need of immune strengthening are the young, the old, and anyone under stress. Almost all of us fall into one of these categories. We often talk of the baby-boom generation. Most of these people are at an age where already their immune systems are becoming lax. Transfer Factor is a way to boost a lagging immune system.
Is transfer factor safe for infants? Colostral transfer factor was designed by Nature for newborns. Removal of the milk allergens and lactose leaves only the essence of the immunological information in the form of Transfer Factor™.
Are there studies to back up the power of transfer factors? There have been over 3000 medical studies completed and 40 million dollars spent in researching the benefits of transfer factors. 4Life Transfer Factor™ and Transfer Factor Plus™ were tested for their ability to increase Natural Killer Cell (NK) activity by the Institute of Longevity Medicine in California. Natural Killer Cells seek and destroy harmful cells through direct contact. Natural Killer Cells are especially important in strengthening and supporting the immune system. Test results showed that 4Life Transfer Factor™ boosted NK cell activity 103% above normal immune response without supplementation, more than two times higher than the next highest product. The study also showed that Transfer Factor Plus™ increased the NK cell activity over 430% above normal immune response without supplementation, or about five times higher than any of the other previously tested products. With the ability of transfer factors to boost the immune system this will help stop the overuse of antibiotics. According to David Markowitz, M.D. who has been running a clinical trial in his pediatric practice, "In an aged match review of transfer factor users we have seen 74% less reported illness and 84% less use of antibiotics."
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Michael Traub, N.D.- "The period once euphemistically called the Age of the Miracle Drug is now dead. And the indiscriminate use of antibiotics is leading us to one of the most frightening eras in recent memory. That is, the return of infectious diseases for which there is no effective treatment. Two decades following the introduction of antibiotics, the medical community began to see a disturbing trend. Bacterial infections that were once treatable no longer responded to antibiotics. Penicillin is effective today against only 10 percent of the strains of Staphylococcus aureus that it used to eradicate easily. Those that did respond often required five to ten times the dose of the drug that previously was effective. One example of this is the resistant strains of gonorrhea that developed as a result of the antibiotics that were used to treat it."
Transfer Factors Supplementation: Modulating and Strengthening the Immune System
 Transfer factors are tiny molecules found in colostrum which provide "immune knowledge" from a mother's immune system to her baby used in recognizing and fighting outside threats. By transferring information from cell to cell, transfer factors serve as "teachers" to the new cells, ensuring a strong immune system capable of surviving, even thriving, in its new environment.* Transfer factors are not species-specific and can therefore be extracted from any mammal and then be given to another mammal with the same efficacy.
There are over 3,000 published papers and 50 years of research on transfer factors. There has also been a lab study and a human study done with these products. In addition, the International Transfer Factor Society sponsors an International Symposium every three years on the findings of transfer factor research. The Eleventh International Transfer Factor Congress was held in Monterey, Mexico in March of 1999.
We all know the importance of an optimal immune system, not only after surgical procedures or fighting disease and serious illness, but also in your patient's or pet's everyday wellness. Recent in vitro and in vivo studies on Transfer Factor documented an increase in Natural Killer cell activity by 248% and 269% respectively, over baseline immune response. The NK cell is the animal's first line of defense against many pathogens... bacteria, viruses, parasites, and of course malignant tumor cells.
Rob Robertson, MD - "Transfer factors are tiny protein molecules that are produced by immune cells called T-cells. It allow the immune system to remember conditions for which immunity has already been established. When a person has been infected, for example, with chicken pox in childhood, their body develops a memory of that illness, and prevents the person from becoming re-infected with it later in life. In the future, the specific immune transfer factor molecule for chicken pox will endow the immune system with the exact ‘blueprint’ of what chicken pox looks like, and the body will be able to quickly recognize and respond to any possible re-infection. Many of these transfer factors - or "immune memory molecules," were introduced to us from our mother’s milk or colostrum, which is the richest source of concentrated transfer factors known to scientists. Transfer factors in colostrum have the sole purpose of transferring immunity from the mother to the baby’s immature immune system. All mammals produce transfer factor, but scientists prefer to work with chicken and normal bovine colostrum. A healthy cow already produces millions of different transfer factors, but when the cow comes into contact with a pathogen such as a virus, it produces a new transfer factor for that specific virus or pathogen. For individuals challenged by specific pathogens – such as those suffering with chronic illnesses like Chronic Fatigue Syndrome, supplementation with the appropriate transfer factor molecule may provide the ‘missing link,’ thereby allowing the immune system to target and destroy the offending pathogen, and mitigate the symptoms of the disease." Dr. Robertson is a former Emergency Room Physician. He received his medical degree from the University of Louisville School of Medicine in 1974. He served as the Director of Emergency Services at Western Baptist Hospital in Paducah, KY.
In 1949, Dr. H. Sherwood Lawrence made a revolutionary discovery while studying tuberculosis. He determined that an immune response could be transferred from a donor to a recipient by injecting an extract of white blood cells (leukocytes) from a previously infected, now healthy, subject into a newly infected patient. He found that this extract contained a factor capable of transferring immunity. He named the substance "transfer factor."
Dr. Lawrence's discovery came in the midst of the discovery and use of antibiotics. Transfer factors have been used throughout the antibiotic age in different regions of the world such as China, Poland, Italy and others, but never have been available commercially due to the lack of technology.
In the fifty years since Lawrence's pioneering work, an estimated $40,000,000 has been spent on research resulting in over 3,000 published scientific papers documenting the benefits of transfer factors. The world's leading scientists and physicians have established the safety and remarkable immune system benefits of transfer factors. The processing methods that allow for large-scale extraction of transfer factors have only recently been perfected and a commercial product has only been available within the last few years.
Greg B. Wilson, Ph.D. and James B. Daily, Jr., Ph.D. - "Transfer factors are small molecular messengers produced by immune T lymphocytes. The message they provide is a specific description of an invading pathogen. Using transfer factors, immune T lymphocytes can transfer the ability to recognize and invading pathogen to previously naïve lymphocytes. In other words, one T lymphocyte tells another what the enemy looks like so that a coordinated attack can be mounted." Learn more: Transfer Factors & Immunity
Duane Townsend, MD - "I’m a cancer physician. I primarily treat female cancer, and certainly encourage my patients who are undergoing chemotherapy and radiation therapy to take transfer factors. It helps to modulate the immune system. I have patients with chronic herpes infections who are taking transfer factors on a regular basis, and it’s reducing the number of outbreaks. I’ve also had patients with chronic yeast infections, and the transfer factors have reduced their infections as well. Transfer factors are science-based with excellent data from a variety of researchers." Dr. Townsend has had more than 32 years of distinguished experience in the medical field. He pioneered a surgical technique for the treatment of pre-malignant disease of the uterine cervix. In addition, he has authored more than 90 scientific papers in peer review journals as well as over 15 chapters in research books.
Kenneth Bock, MD - "Because transfer factors can function as immune system modulators, they can help to restore immune system balance in many types of clinical situations."Kenneth Bock, MD, best selling author on immune system modulation.
Richard Bennett, PhD - "The immunity provided by transfer factors is long lived and can help all ages who are suffering from a variety of ailments or those who want to stay well. The unfolding events surrounding Severe Acute Respiratory Syndrome, (SARS) is yet another painful reminder that we live in a crowded world where continents are only a plane ride away. The SARS epidemic is only one of an ongoing series of new emerging diseases. Our best global and personal strategy is to do all in our power to ensure and support our unique abilities of disease resistance and immunity” Dr. Bennett is an Infectious Disease Microbiologist ? Immunologist, who is enjoying retirement from a 21-year career with the University of California where he specialized in food and water quality and safety. He received his Doctorate in Comparative Pathology from the University of California, Davis. He has an extensive background in milk quality and disease control, water resource policy, food safety, public policy of natural resources, etc. He has also served as an advisor for the FDA and USDA.
Rob Robertson, MD - "I believe transfer factors are, without a doubt, the greatest discovery of the century in supporting and modulating the immune system. I believe a strengthened immune system will be the primary way to stay well in the future. This nutrient can affect the immune system like nothing else can. I sincerely believe everyone needs to consume this product. There is no other product in a nutritional substance, nor a drug, that has this kind of power and ability to affect our immune system. With the increase of killer viruses, mutated germs, super-resistant germs, and food contaminations, our only hope and defense, must lie within our own immune system." Dr. Robertson is a former Emergency Room . He received his medical degree from the University of Louisville School of Medicine in 1974. He served as the Director of Emergency Services at Western Baptist Hospital in Paducah, KY..
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